TY - JOUR AU - Parry, Lee AU - Phesse, Toby J. PY - 2019 TI - FXR regulates intestinal stem cells response to bile acids in a high fat diet JF - Biotarget; Vol 3 (July 2019): Biotarget Y2 - 2019 KW - N2 - Although a high fat diet (HFD) is known to be associated with a poor clinical outcome for colorectal cancer (CRC) patients, the precise mechanisms underlying this are poorly understood. Fu and colleagues have recently identified high levels of bile acid (BA) in a preclinical mouse model of colon cancer, and that a HFD increases BA further which in turn promotes proliferation in Lgr5+ stem cells, via inhibition of farnesoid X receptor (FXR), to drive tumour progression (1). UR - https://biotarget.amegroups.org/article/view/5065