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FXR regulates intestinal stem cells response to bile acids in a high fat diet

  
@article{Biotarget5065,
	author = {Lee Parry and Toby J. Phesse},
	title = {FXR regulates intestinal stem cells response to bile acids in a high fat diet},
	journal = {Biotarget},
	volume = {3},
	number = {0},
	year = {2019},
	keywords = {},
	abstract = {Although a high fat diet (HFD) is known to be associated with a poor clinical outcome for colorectal cancer (CRC) patients, the precise mechanisms underlying this are poorly understood. Fu and colleagues have recently identified high levels of bile acid (BA) in a preclinical mouse model of colon cancer, and that a HFD increases BA further which in turn promotes proliferation in Lgr5+ stem cells, via inhibition of farnesoid X receptor (FXR), to drive tumour progression (1).},
	url = {http://biotarget.amegroups.com/article/view/5065}
}