Article Abstract

Wnt7a and miR-370-3p: new contributors to bladder cancer invasion

Authors: Danielle Scheunemann, Anjan K. Pradhan, Swadesh K. Das, Devanand Sarkar, Luni Emdad, Paul B. Fisher

Abstract

In eukaryotes, microRNAs (miRNAs) are central regulators of gene expression. These small noncoding RNAs are about 19–24 nucleotides long (1). miRNAs can silence gene expression by binding to a complementary sequence in the 3'-UTR of the target gene, which then triggers mRNA degradation.