Article Abstract

The expanding complexity of the phosphorylation and proteolytic signaling axis of MST1

Authors: Luana C. A. Leitao, Alaa M. Ismail, Richard P. Fahlman


The mammalian STE20-like kinases 1 and 2 (MST1 and MST2) have been widely investigated with their identified roles in the Hippo signaling pathway which regulates organ size (1) through the regulation of the TAZ and YAP effectors (2). While diverse cellular networks are impacted by the Hippo signaling pathway, including diverse signaling networks and global microRNA biogenesis (3,4), novel functions for the MST proteins emerge upon proteolysis of these kinases.