Mitochondrial ribosome-binding factor A (mtRBFA): mediator of rRNA methylation and maturation

Brooke E. Christian

Abstract

Mitochondria are organelles perhaps most famous for energy production by oxidative phosphorylation (OXPHOS). In addition to producing ATP, mitochondria are multi-faceted organelles that mediate processes such as autophagy, differentiation, calcium homeostasis, and the immune response (1,2). Mitochondrial dysfunction has been implicated in a number of diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and diabetes, to name a few (3).